abstract：:We describe a case of generalized, asymptomatic, chronic annular lichen planus. The centers of the large annular lesions were atrophic and had lost their elasticity. Histologic examination revealed an absence of elastic fiber in the center. Electron microscopy revealed fragmented elastic fibers. Examination of early l...

journal_title：Journal of the American Academy of Dermatology

authors： Friedman DB,Hashimoto K

更新日期：1991-08-01 00:00:00

abstract：:To evaluate the possible association of other malignancies with basal cell carcinoma, we reviewed 1973 consecutive patients with basal cell carcinoma. We searched the Swedish Cancer Registry for records reporting malignancies in the study population (1958-1984) and the expected number of malignancies was calculated on...

journal_title：Journal of the American Academy of Dermatology

authors： Lindelöf B,Sigurgeirsson B,Wallberg P,Eklund G

更新日期：1991-08-01 00:00:00

abstract：:Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the imp...

journal_title：Journal of the American Academy of Dermatology

authors： Olsen EA

更新日期：1991-08-01 00:00:00

abstract：:Angioedema is characterized by localized swelling of sudden onset affecting the skin and/or mucous membranes. It can be classified into hereditary and acquired forms. Hereditary angioedema is a rare disease inherited as an autosomal dominant trait and caused by a deficiency of C1-esterase inhibitor. Acute attacks are ...

journal_title：Journal of the American Academy of Dermatology

authors： Greaves M,Lawlor F

更新日期：1991-07-01 00:00:00

abstract：:Blisters from five patients with porphyria cutanea tarda and two patients with drug-induced pseudoporphyria were examined by direct immunofluorescence and by immunofluorescence mapping with antibodies against laminin and type IV collagen to determine the level of subepidermal separation. Primary screening by direct im...

journal_title：Journal of the American Academy of Dermatology

authors： Dabski C,Beutner EH

更新日期：1991-07-01 00:00:00

abstract：:Cytokines are glycoproteins produced by many different cells. Via binding to specific receptors on target cells they regulate the activation, differentiation, and proliferation of immune and nonimmune cells. After injury keratinocytes synthesize and release cytokines such as interleukins, colony stimulating factors, a...

journal_title：Journal of the American Academy of Dermatology

authors： Luger TA,Schwarz T

更新日期：1991-06-01 00:00:00

abstract：:Lymphocyte function as expressed by T-lymphocyte subsets and natural killer cell activity was evaluated in a group of Israeli patients with classic Kaposi's sarcoma. T-cell subsets were examined in 28 patients, 14 with lesions limited to the lower extremities and 14 with diffuse cutaneous or systemic involvement. CD4 ...

journal_title：Journal of the American Academy of Dermatology

authors： Friedman-Birnbaum R,Weltfriend S,Pollack S

更新日期：1991-06-01 00:00:00

abstract：:Many cutaneous diseases have been reported in patients with human immunodeficiency virus infection. We report two patients with pityriasis rubra pilaris and human immunodeficiency virus infection. In one patient, the onset of pityriasis rubra pilaris preceded the discovery of human immunodeficiency virus infection. In...

journal_title：Journal of the American Academy of Dermatology

authors： Blauvelt A,Nahass GT,Pardo RJ,Kerdel FA

更新日期：1991-05-01 00:00:00

abstract：:Verruciform xanthomas occur on mucocutaneous surfaces and are characterized by hyperkeratosis, acanthosis, and the occurrence of "foam cells" stuffed with lipid surrounding capillaries in the dermis between rete pegs. Ultrastructural examination of a lesion on the penis revealed the presence of melanocytes with many l...

journal_title：Journal of the American Academy of Dermatology

authors： Balus S,Breathnach AS,O'Grady AJ

更新日期：1991-05-01 00:00:00

abstract：:The Papillon-Lefèvre syndrome is characterized by palmoplantar hyperkeratosis and juvenile periodontitis that results in the precocious loss of both the deciduous and permanent teeth. We report a patient with Papillon-Lefèvre syndrome associated with acroosteolysis, an association that has not been previously describe...

journal_title：Journal of the American Academy of Dermatology

authors： Trattner A,David M,Sandbank M

更新日期：1991-05-01 00:00:00

abstract：:Palpable purpura in a follicular localization developed in association with acute epididymitis in a white man who was seropositive for the human immunodeficiency virus (HIV). Biopsy specimens revealed a leukocytoclastic vasculitis with follicular accentuation. With antibiotic therapy the vasculitis resolved, but it re...

journal_title：Journal of the American Academy of Dermatology

authors： Weimer CE Jr,Sahn EE

更新日期：1991-05-01 00:00:00

abstract：:Both etretinate and its principal metabolite, acitretin, are efficacious in the treatment of psoriasis. Because patients with severe psoriasis often require chronic therapy, this study was undertaken to determine the efficacy, tolerability, and safety of acitretin in patients on continuous treatment for 12 months. The...

journal_title：Journal of the American Academy of Dermatology

authors： Murray HE,Anhalt AW,Lessard R,Schacter RK,Ross JB,Stewart WD,Geiger JM

更新日期：1991-04-01 00:00:00

abstract：:An association between HLA-DR1 and the development of multiple basal cell carcinomas was detected in southern Australia. A reduction in HLA-DR4 was found in patients with basal cell carcinoma compared with a local control group. The relative risk for HLA-DR1 was 2.1, which was lower than that for persons in farther co...

journal_title：Journal of the American Academy of Dermatology

authors： Czarnecki D,Lewis A,Nicholson I,Tait B

更新日期：1991-04-01 00:00:00

abstract：:A 56-year-old man had a deeply invasive leiomyosarcoma of the right buttock. Leiomyosarcomas of the skin and subcutaneous tissues are rare, and most occur on the extremities. Wide local excision is the therapy of choice. ...

journal_title：Journal of the American Academy of Dermatology

authors： Landry MM,Sarma DP,Boucree JB Jr

更新日期：1991-04-01 00:00:00

abstract：:A recent study demonstrated that hirsute women with irregular menses had higher levels of serum androgens that hirsute women with regular menses. To investigate this finding, we measured total testosterone, biologically active testosterone, free testosterone, androstenedione, dehydroepiandrosterone, and dehydroepiandr...

journal_title：Journal of the American Academy of Dermatology

authors： Salman K,Spielvogel RL,Miller JL,Rose LI

更新日期：1991-03-01 00:00:00

abstract：:Six months after the occurrence of pyoderma gangrenosum, subcorneal pustular dermatosis developed in a 60-year-old woman. The patient's serum was found to contain an IgA-lambda paraprotein. Although similar cases have been reported, this case is unique in that a distinct episode of pyoderma gangrenosum was followed by...

journal_title：Journal of the American Academy of Dermatology

authors： Kohl PK,Hartschuh W,Tilgen W,Frosch PJ

更新日期：1991-02-01 00:00:00

abstract：:Xeroderma pigmentosum is associated with severe actinic degeneration of the skin. Our patient with xeroderma pigmentosum showed increasing actinic damage in some areas covered by clothes. We therefore performed a complete evaluation of the patient's exposure to ultraviolet radiation. This included transmission measure...

journal_title：Journal of the American Academy of Dermatology

authors： Bech-Thomsen N,Wulf HC,Ullman S

更新日期：1991-02-01 00:00:00

abstract：:To determine whether systemic hydrocortisone can elicit allergic skin reactions in patients with contact hypersensitivity to hydrocortisone, we studied four patients with contact hypersensitivity to hydrocortisone and hydrocortisone-17-butyrate and two patients with contact hypersensitivity to hydrocortisone-17-butyra...

journal_title：Journal of the American Academy of Dermatology

authors： Lauerma AI,Reitamo S,Maibach HI

更新日期：1991-02-01 00:00:00

abstract：:Bowenoid papulosis is an uncommon genital dysplasia induced by human papillomavirus infection. Clinically, it usually resembles persistent warts, but histologically it may be suggestive of squamous cell carcinoma in situ. This unusual disorder and recent advances in our understanding of it are reviewed. ...

journal_title：Journal of the American Academy of Dermatology

authors： Schwartz RA,Janniger CK

更新日期：1991-02-01 00:00:00

abstract：:In a pilot study the therapeutic effect and side effect profile of low-dose interferon alfa-2b in combination with a retinoid for the treatment of cutaneous T cell lymphoma were evaluated. Seven patients (four women, three men) with histologically confirmed cutaneous T cell lymphoma were included. Four patients had re...

journal_title：Journal of the American Academy of Dermatology

authors： Knobler RM,Trautinger F,Radaszkiewicz T,Kokoschka EM,Micksche M

更新日期：1991-02-01 00:00:00

abstract：:Small erythematous or cyanotic lesions on the hands and feet of four patients with antiphospholipid antibodies are described. These discrete lesions outline capillaries and do not disappear when pressure is applied. The histologic features are identical to those described in skin thrombotic syndrome associated with an...

journal_title：Journal of the American Academy of Dermatology

authors： Grob JJ,San Marco M,Aillaud MF,Andrac L,Gabriel B,Juhan-Vague I,Mercier C,Bonerandi JJ

更新日期：1991-01-01 00:00:00

abstract：:Multiple cell types and their factors and cytokines are involved in regulating the immune response in inflammatory skin diseases. Stimulatory and inhibitory factors interact to determine whether the immune response is regulated up or down. Normally, stimulatory signals are counteracted by inhibitory signals to prevent...

journal_title：Journal of the American Academy of Dermatology

authors： Baadsgaard O,Fisher GJ,Voorhees JJ,Cooper KD

更新日期：1990-12-01 00:00:00

abstract：:Neutrophilic eccrine hidradenitis is an uncommon, self-limited dermatosis with a variable clinical presentation. It seems to be due to chemotherapeutic drugs in most cases. Necrosis of the eccrine gland associated with a neutrophilic infiltrate is the histologic hallmark of this disease. We report two additional cases...

journal_title：Journal of the American Academy of Dermatology

authors： Allegue F,Soria C,Rocamora A,Muñoz E,Freire-Murgueytio P,Arrazola JM,Ledo A

更新日期：1990-12-01 00:00:00

abstract：:Five families with the dysplastic nevus syndrome, in each of which one member had ocular melanoma, are reported. These five families were examined within a 3-year period in one medical center. To date only five other families with such a combination have been reported. We suggest a causal relation between ocular melan...

journal_title：Journal of the American Academy of Dermatology

authors： Vink J,Crijns MB,Mooy CM,Bergman W,Oosterhuis JA,Went LN

更新日期：1990-11-01 00:00:00

abstract：:This article reports the cases of two patients in whom a widespread dermatophyte infection mimicked the cutaneous lesions of their underlying collagen vascular disease. Griseofulvin may be associated with an increased incidence of adverse cutaneous reactions in patients with systemic lupus erythematosus. One patient w...

journal_title：Journal of the American Academy of Dermatology

authors： Almeida L,Grossman M

更新日期：1990-11-01 00:00:00

abstract：:We report the case of an otherwise healthy 37-year-old man who had had bilateral enucleation during early childhood for bilateral retinoblastomas, in addition to two cutaneous melanomas (the first appearing at age 27 years). He also had dysplastic melanocytic nevi and a history of cutaneous melanoma in his mother. Ret...

journal_title：Journal of the American Academy of Dermatology

authors： Albert LS,Sober AJ,Rhodes AR

更新日期：1990-11-01 00:00:00

abstract：:Vulvar melanosis is a condition in which intensely pigmented irregular macules, clinically mimicking malignant melanoma, appear on the vulva. A biopsy specimen shows only marked lower epidermal pigmentation without any melanocytic atypia or nesting. The process is benign, and reassurance is the only treatment. ...

journal_title：Journal of the American Academy of Dermatology

authors： Rudolph RI

更新日期：1990-11-01 00:00:00

abstract：:Sixty-eight cutaneous squamous cell neoplasms (in situ and invasive) and 26 basal cell carcinomas from 89 patients were analyzed for DNA sequences homologous to the human papillomavirus (HPV) types found predominantly in the genital tract. Thirty-six (53%) of the squamous cell neoplasms contained HPV DNA as detected b...

journal_title：Journal of the American Academy of Dermatology

authors： Eliezri YD,Silverstein SJ,Nuovo GJ

更新日期：1990-11-01 00:00:00

abstract：:We performed a 22-month trial of topical tretinoin (retinoic acid) in the treatment of photoaging. Thirty patients participated in a 4-month, randomized, blinded, vehicle-controlled study that has been reported previously; 21 patients continued tretinoin therapy on an open-label basis, participating in the study for a...

journal_title：Journal of the American Academy of Dermatology

authors： Ellis CN,Weiss JS,Hamilton TA,Headington JT,Zelickson AS,Voorhees JJ

更新日期：1990-10-01 00:00:00

abstract：:Significant progress has been made in skin replacement options in the past several decades. Although initially various materials have been used mainly for burn coverage, their application to dermatologic practice has increased significantly. We review the research, progress, and other aspects of wound coverage with sy...

journal_title：Journal of the American Academy of Dermatology

authors： Límová M,Grekin RC

更新日期：1990-10-01 00:00:00

abstract：:The presence of mast cells, often in an activated state or increased numbers, has been noted in various cutaneous disorders. Recent studies suggest that mast cells are of primary importance in these conditions and their presence does not merely represent a secondary event. This review focuses on atopic dermatitis, con...

journal_title：Journal of the American Academy of Dermatology

authors： Rothe MJ,Nowak M,Kerdel FA

更新日期：1990-10-01 00:00:00

abstract：:This study compares the histopathologic characteristics of photodistributed and nonphotodistributed lichenoid drug eruptions in 13 patients. Both types have been said to be, in an unknown proportion, different from idiopathic lichen planus in that they can involve the deep as well as the superficial plexus, can contai...

journal_title：Journal of the American Academy of Dermatology

authors： West AJ,Berger TG,LeBoit PE

更新日期：1990-10-01 00:00:00

abstract：:Striking results were obtained with oral itraconazole therapy in two opportunistic mycoses. Of 28 patients with cryptococcal meningitis, 18 achieved complete responses, including 16 of 24 patients with acquired immunodeficiency syndrome. Other manifestations of cryptococcosis were similarly responsive. In aspergillosi...

journal_title：Journal of the American Academy of Dermatology

authors： Denning DW,Tucker RM,Hanson LH,Stevens DA

更新日期：1990-09-01 00:00:00

abstract：:Disseminated histoplasmosis is being diagnosed more frequently in persons infected with the human immunodeficiency virus and is often the initial manifestation of the acquired immunodeficiency syndrome (AIDS). Disease-related cutaneous features of HIV-associated disseminated histoplasmosis are defined as mucocutaneous...

journal_title：Journal of the American Academy of Dermatology

authors： Cohen PR,Bank DE,Silvers DN,Grossman ME

更新日期：1990-09-01 00:00:00

abstract：:Keratoacanthomas infrequently are treated by radiotherapy. However, keratoacanthomas that are recurrent after surgical excision or whose resection would result in cosmetic deformity may benefit from radiotherapy. Between January 1970 and June 1988, 29 such keratoacanthomas in 18 patients were irradiated. Doses ranged ...

journal_title：Journal of the American Academy of Dermatology

authors： Donahue B,Cooper JS,Rush S

更新日期：1990-09-01 00:00:00

abstract：:The number of cases of mycotic infections are increasing, presenting physicians today with an unprecedented challenge in handling the treatment and prophylactic control of these disorders. The increase in mycotic disorders is due to many factors, such as longer life span, organ transplantation, and the acquired immuno...

journal_title：Journal of the American Academy of Dermatology

authors： Jacobs PH

更新日期：1990-09-01 00:00:00

abstract：:Cultured epidermal sheets were examined before and at various times after grafting on skin ulcer beds. Before grafting, the sheet consisted of four to five layers of keratinocytes with incomplete differentiation. Ten days after grafting, graft recipient sites showed compact hyperkeratosis, a normal-appearing epidermis...

journal_title：Journal of the American Academy of Dermatology

authors： Phillips TJ,Bhawan J,Leigh IM,Baum HJ,Gilchrest BA

更新日期：1990-08-01 00:00:00

abstract：:Neutrophilic dermatosis developed in two patients with myelodysplastic syndrome. Biopsy specimens of their skin lesions showed marked infiltration by neutrophils with nuclear anomalies, that is, hyposegmentation (pseudo-Pelger-Huët anomaly) or hypersegmentation. Peripheral blood and bone marrow neutrophils had similar...

journal_title：Journal of the American Academy of Dermatology

authors： Morioka N,Otsuka F,Nogita T,Igisu K,Urabe A,Ishibashi Y

更新日期：1990-08-01 00:00:00

abstract：:An acute localized, purulent skin lesion developed on the right knee of an 8-year-old girl and was subsequently diagnosed as a primary cutaneous Nocardia brasiliensis infection. It was soon accompanied by intense lymphangitis and regional adenopathy. The patient had a history of a minor abrasion contaminated by soil a...

journal_title：Journal of the American Academy of Dermatology

authors： Hironaga M,Mochizuki T,Watanabe S

更新日期：1990-08-01 00:00:00

abstract：:The use of fingerprints for personal identification became widespread early in this century. How the fingerprints slowly became standardized involves many persons, including Nathaniel Grew, Johannes Purkinje, William Herschel, Henry Faulds, Charles Darwin, Francis Galton, Mark Twain, Juan Vucetich, Edward Henry, and J...

journal_title：Journal of the American Academy of Dermatology

authors： Caplan RM

更新日期：1990-07-01 00:00:00